). However, it remains unclear whether vibrotactile stimulation at gamma frequencies can also reduce pathological features in the brain, similar to visual and auditory GENUS.
Number of c-Fos positive cells in SSp and MOp of 4-month-old C57BL/6 J mice after 1 h of no stimulation or 40 Hz vibrotactile stimulation, normalized to the average of no stimulation controls .-test. Each circle represents an individual mouse, each bar represents the mean, and error bars represent SEM.
An empty mouse cage with a metal wire cage lid was placed on top of each speaker near its center . To prevent the cage from falling off the vibrating speaker during vibration, the cage and lid were held in place by two rubber bands that were clamped to the top of the lid on one end and the rim of the speaker on the other end . The vibration inside the vibrating cage was at 40 Hz with about 16 μm displacement, as measured by an accelerometer.
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Frontiers | Effect of nutrition in Alzheimer’s disease: A systematic reviewBackground and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by declining cognitive ability. Currently, there are no effective treatments for this condition. However, certain measures, such as nutritional interventions, can slow disease progression. Therefore, the objective of this systematic review was to identify and map the updates of the last five years regarding the nutritional status and nutritional interventions associated with AD patients. Study Design: A Systematic Review Methods: A search was conducted for randomized clinical trials, systematic reviews, and meta-analyses investigating the association between nutritional interventions and AD published between 2018 and 2022 in the PubMed, Web of Science, Scopus, and Cochrane Library databases. A total of 38 studies were identified, of which 17 were randomized clinical trials, and 21 were systematic reviews and/or meta-analyses. Results: The results show that the western diet pattern is a risk factor for developing AD. In contrast, the Mediterranean diet, ketogenic diet, and supplementation with omega-3 fatty acids and probiotics are protective factors. This effect is significant only in cases of mild-to-moderate AD. Conclusion: Certain nutritional interventions may slow the progression of AD and improve cognitive function and quality of life. Further research is required to draw more definitive conclusions.
Source: medical_xpress - 🏆 101. / 51 Read more »
Frontiers | Effect of nutrition in Alzheimer’s disease: A systematic reviewBackground and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by declining cognitive ability. Currently, there are no effective treatments for this condition. However, certain measures, such as nutritional interventions, can slow disease progression. Therefore, the objective of this systematic review was to identify and map the updates of the last five years regarding the nutritional status and nutritional interventions associated with AD patients. Study Design: A Systematic Review Methods: A search was conducted for randomized clinical trials, systematic reviews, and meta-analyses investigating the association between nutritional interventions and AD published between 2018 and 2022 in the PubMed, Web of Science, Scopus, and Cochrane Library databases. A total of 38 studies were identified, of which 17 were randomized clinical trials, and 21 were systematic reviews and/or meta-analyses. Results: The results show that the western diet pattern is a risk factor for developing AD. In contrast, the Mediterranean diet, ketogenic diet, and supplementation with omega-3 fatty acids and probiotics are protective factors. This effect is significant only in cases of mild-to-moderate AD. Conclusion: Certain nutritional interventions may slow the progression of AD and improve cognitive function and quality of life. Further research is required to draw more definitive conclusions.
Source: medical_xpress - 🏆 101. / 51 Read more »