A new first-line antiretroviral drug regimen scheduled to be introduced in public health facilities in South Africa in September has been given the thumbs up by SA scientists.
The study compared two new drug-regimens against an efavirenz -containing regimen, EFV being the current most commonly used first-line drug treatment in South Africa and in many parts of Africa. The two treatments tested are a dolutegravir -containing regimen and a tThe results have shown that both new drug regimens are as effective and safe as EFV-containing regimens.
Venter says: “All regimens, the new ones studied and the one South Africa uses currently , rapidly and effectively suppressed HIV. The regimens were also all very safe, with minimal side effects that we generally worry about – to bone, kidneys, liver and neuropsychiatric side-effects. The one surprising side effect was weight gain, especially among women.”
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