It is a drug that has dominated headlines, first as a medication for type 2 diabetes, then as a weight-loss aid. Now it seems semaglutide – often called by its brand names Ozempic or Wegovy – could bring benefits in myriad areas of healthcare, from addiction to dementia.Semaglutide, which can be taken as a tablet or via injection, mimics a hormone produced in the body called GLP-1 – a substance that is released in the gut when we eat.
“Previously, the only evidenced and effective long-term treatment for obesity was weight-loss surgery where we have evidence that surgery is capable of giving long-term weight loss for 20 years or so. This trial helps to support the idea that semaglutide is effective at least in the medium-term.”The results have led some experts to suggest semaglutide should be routinely prescribed to treat cardiovascular illnesses.
When it comes to dementia, there are several mooted mechanisms by which semaglutide might being benefits, from reducing inflammation in the brain, to reducing the accumulation of proteins While Koychev is optimistic, it is worth noting many highly promising dementia drugs have fallen by the wayside as trials progressed.This is a promising area for semaglutide given the drug appears to not only dampen the reward system associated with food but drugs, too.However large scale, robust studies in humans are needed, while it is unclear if such drugs dampen reward signalling generally in the brain – raising concerns around their use in people with depression.
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