Based on Patrick Radden Keefe's New Yorker exposé "Purdue Pharma's reckless and deceptive marketing of OxyContin in the 1990s as safe, effective and non-addictive pain management.
[Richard Sackler] came up with a plan to take what is essentially heroin and put it into a little pill, and have doctors manipulate doctors into prescribing it.The show depicts multiple sides of the opioid epidemic — from the pawns used to push the drug, to the doctors who prescribed it, to the victims whose lives were devastated by addiction — but a substantial amount of screen time is devoted to exposing the Sackler family, the founders and owners of Purdue Pharma.