The mouse metaverse: A tool for understanding the molecular mechanism of autism and the mind

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Autism is difficult to study and more difficult to treat because it is an individual condition lacking precise quantification. The development of mouse models of human mental disorders has proven a tractable approach to studying the molecular mechanisms, a new review argues, and highlights the current state of the art in autism research.

One such technology is the development of mouse models of human mental disorders, of which Takumi is a pioneer. Genetically modified mice that exhibit social behavior disorders offer a unique opportunity to accurately analyze the molecular and physiological mechanisms behind autism and to test potential treatment approaches.

"Psychiatric disorders, in general, are considered to be neurocircuit disorders, and therefore, the elucidation of the neural circuitry in social behavior will lead to the development of future neurocircuit-based therapies," explains Takumi. One intriguing method to study how molecular dysfunctions cause social maladaptation is what Takumi calls the"mouse metaverse."

 

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