The researchers therefore investigated whether intensive blood pressure management would result in better clinical outcomes in the 24 hours after successful recanalization with IAT.
Clinicians could use local treatment protocols based on available IV blood pressure-lowering drugs. Blood pressure was measured every 15 minutes for the first hour after randomization and then hourly for 24 hours. The mean age was 73.1 years, and 40.3% were women. The average National Institutes of Health Stroke Scale score prior to IAT was 13. The mean time from stroke onset to randomization was 480 minutes .
Crucially, Nam showed that patients in the intensive blood pressure lowering group were significantly less likely than those in the conventional group to have a favorable outcome, defined as a modified Rankin scale score of 0-2, at 3 months, at 39.4% vs 54.4%, or an adjusted odds ratio of 0.56 . There was also no difference in the rate of death related to the index stroke within 90 days, at 7.7% vs 5.4% .
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