Assessing the relationship between gut microbiota and irritable bowel syndrome: a two-sample Mendelian randomization analysis - BMC Gastroenterology

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A study published in BMCGastroEnterol finds a potential causal relationship between several gut microbiota taxa and the risk of irritable bowel syndrome, which may provide clues for the pathogenesis and novel treatment of IBS.

Liu Y, Zhang L, Wang X, Wang Z, Zhang J, Jiang R, Wang X, Wang K, Liu Z, Xia Z: Similar fecal microbiota signatures in patients with diarrhea-predominant irritable bowel syndrome and patients with depression. Clin Gastroenterol Hepatol. 2016; 14:1602–1611. e1605.

Laatikainen R, Jalanka J, Loponen J, Hongisto S-M, Hillilä M, Koskenpato J, Korpela R, Salonen A. Randomised clinical trial: effect of low-FODMAP rye bread versus regular rye bread on the intestinal microbiota of irritable bowel syndrome patients: association with individual symptom variation. BMC Nutrition. 2019;5:1–11.Zhou Y, Zhang F, Mao L, Feng T, Wang K, Wang X, Xu M, Lv B.

Andriulli A, Bevilacqua A, Palmieri O, Latiano A, Fontana R, Gioffreda D, Castellana S, Mazza T, Panza A, Menzaghi C. Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly™ bread in celiac subjects: a randomized, double blind, placebo control in vivo study. Food Funct. 2022;13:1299-315.

Wu X, Xu N, Ye Z, Zhao Q, Liu J, Li J, Wu M, Zheng Y, Li X, Li W. Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice. Int J Biol Macromolecules. 2022;206:1-9. Chassard C, Dapoigny M, Scott KP, Crouzet L, Del’Homme C, Marquet P, Martin JC, Pickering G, Ardid D, Eschalier A. Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome. Aliment Pharmacol Ther. 2012;35:828–38.

 

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