You can run. You can hide. You can even leave Woodsboro, But you can’t escape Ghostface. Tis is evident as the masked murderer heads to New York City to wreak havoc among the survivors from Scream V in the trailer for Scream VI.
In Scream V, Sam was revealed to be the illegitimate daughter of Billy Loomis, the original Ghostface from Scream. In the trailer, Sam comments about a “darkness” inside of her that followed her to New York City and will keep coming for her and her friends. That darkness is a bloodier, more violent Ghostface, who follows the Carpenters into a bodega and viciously kills multiple people at the beginning of the trailer.
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