with minor changes. The CPP apparatus consisted of two equal-sized compartments with distinct tactile and visual cues. One compartment was white with a textured floor, and the other one was black with a smooth floor. In pretest sessions on Day 1, mice without the fiber patch cable were allowed to explore two compartments freely for 900 s, and the time spent in each compartment during the exploration period was measured using ANY-maze tracking software .
For the CPA test with drug administration, the mice were injected intraperitoneally with vehicle , WAY-100635 , or MDL-100907 (0.5 mg/kg, 5-HT
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