Microbiomes in female reproductive tract linked to pregnancy following use of ART

By Dr. Liji Thomas, MDDec 9 2022Reviewed by Benedette Cuffari, M.Sc. Various beneficial bacteria reside in the female reproductive tract; however, their role in reproductive function remains unclear. A new JBRA Assisted Reproduction study examines the outcomes of assisted reproductive technology and reports that specific microbial profiles were associated with better conception rates.

Some researchers have previously reported that vaginal dysbiosis, or abnormal alterations in the vaginal microbiota, reduces pregnancy rates following in vitro fertilization ; however, this has been contradicted by several meta-analyses.

All embryos were of good quality and the embryo transfer was carried out if the endometrium was at least 8.0 mm thick on day 15 of the cycle. All microbiome samples were collected between days eight and 10 of the menstrual cycle. Taken together, 34 and 33 vaginal and endometrial samples, respectively, were included in the study.

Among pregnant women, high Lactobacillus abundance was found in both vaginal and endometrial samples compared to high PB in the samples from non-pregnant women. In most cases, the two sample types correlated well.

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