’s fifth album sounds a bit like the end of the world. Every song is woven of layer upon layer of music that has more than a little of the wrath of the heavens about it, rich pealing chorals and strings that dissolve into synths. Each track is like a mini epic, brimming over as she sings in a way that feels desperate and repentant.
The Californian, whose real name is Natalie Mering, seems concerned with the tiny light glowing in the dark: the songs on this album all seem busy and chaotic but there is always a moment of clarity to them, even if that is at the very end – like on “Hearts Aglow”, which flutters into a harp strum after six minutes of searching for hope in a crumbling world.
There’s something monstrous about the sheer wall of sound Weyes Blood has built on this record: the feeling of being closed in on by the music, which echoes the feeling of being bombarded by bad news at every turn .
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Imaging of C-X-C Motif Chemokine Receptor 4 Expression in 690 Patients with Solid or Hematologic Neoplasms Using 68Ga-Pentixafor PETIn recent years, molecular imaging addressing the C-X-C motif chemokine receptor 4 (CXCR4) has increasingly been used in various clinical settings. Here, we aimed to assess radiopharmaceutical uptake and image contrast to determine the most relevant clinical applications for CXCR4-directed imaging. We also investigated the impact of specific activity on scan contrast. Methods: Patients ( n=690) with a variety of neoplasms underwent a total of 777 PET/CT scans with 68Ga-Pentixafor, serving as the CXCR4-specific radioligand. A semiquantitative target lesion analysis was conducted (providing SUVmax and target-to-blood pool ratio [TBR], defined as SUVmax [from target lesion] divided by SUVmean [from blood pool]). The applied specific activity (in MBq/μg) was compared with semiquantitative assessments. Results: Of the 777 scans, 242 did not show discernible uptake in disease sites, leaving 535 PET scans (68.9%) for further analysis. Very high tracer uptake (SUVmax | 12) was found in multiple myeloma ( n=113), followed by adrenocortical carcinoma ( n=30), mantle cell lymphoma ( n=20), adrenocortical adenoma ( n=6), and small cell lung cancer ( n=12). Providing information on image contrast, comparable results for TBR were recorded, with TBR (|8) in multiple myeloma, mantle cell lymphoma, and acute lymphoblastoid leukemia ( n=6). When comparing specific activity with semiquantitative parameters, no significant correlation was found for SUVmax or TBR ( P ≥ 0.612). Conclusion: In this large cohort, 68Ga-Pentixafor demonstrated high image contrast in a variety of neoplasms, particularly for hematologic malignancies, small cell lung cancer, and adrenocortical neoplasms. The present analysis may provide a roadmap for detecting patients who may benefit from CXCR4-targeted therapies.
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