Simone Inzaghi's side overcame the absence of several key players as they cut the gap between themselves and leading pair Juventus and Inter Milan to three points after scoring an injury-time winner for the third away game in row.
Lazio had to reshuffle their midfield as Lucas Leiva and Luis Alberto -- their key assist-provider this season -- were both suspended while Danilo Cataldi was not fully fit. However, Brescia, who have enjoyed a new lease of life since Eugenio Corini was recalled as coach in December one month after being sacked, went ahead with a Mario Balotelli volley in the 18th minute, his first home goal since joining his hometown club this season.
The visitors struggled to break down their 10-man opponents in the second half but yet again won the match at the death as they did in matches away to Sassuolo and Cagliari.